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KMID : 1024520040130060591
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Journal of the Environmental Sciences
2004 Volume.13 No. 6 p.591 ~ p.597
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Study on Estrogenic Activities of Pesticide Chemicals using E-screen Assay
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Han Sang-Kuk
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Abstract
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In this study, sixty chemicals including 47 pesticides were screened for estrogenic activity using E-screen assay. MCF-7 cell, used in E-screen assay, is known to be proliferated by addition of estrogenic chemicals. Eight of the measured pesticides showed estrogenic activity at the concentration range of 100-10,000nM. Their relative proliferative effect (RPE) and the relative proliferative potency (RPP) were 20-65% and 0.01-1.0%, respectively, when compared with 1.0nM of DDVP and diazinone showed most strong estrogenic potency(RPP; 1.0%) and effect(RPE; 65%) of the eight pesticides. These results are in agreement with estrogenic activity of bisphenol A is known as a positive endocrine disrupter. Also, in this study, paraquat, DDVP, 4-chloro-3-methylphenol, 2,4,6-trichlorophenol and diazinon of the measured pesticides are estimated to estrogenic chemical.
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KEYWORD
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MCF-7, E-screen assay, Pesticides, Relative proliferative effect(RPE), Relative proliferative potency (RPP), Estrogenic
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